SERUM SEX HORMONE BINDING GLOBULIN (SHBG) CONCENTRATIONS ARE NOT AFFECTED BY THE ESTROGEN MILIEU IN FEMALE CENTRAL PRECOCIOUS PUBERTY (CPP)
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چکیده
منابع مشابه
Sex Hormone-binding Globulin (shbg) in the Ovary
La proteïna transportadora de les hormones sexuals (SHBG) va ser descrita a finals dels anys seixanta amb les funcions de transportar els esteroides sexuals i de regular-ne la biodisponibilitat. Des de fa ja bastant temps, es coneix també que les cèll . ules testiculars de Sertoli expressen la proteïna que lliga els andrògens (androgen-binding protein oABP), que està codificada pel mateix gen q...
متن کاملInteraction of lignans with human sex hormone binding globulin (SHBG).
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowe...
متن کاملSex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.
The human serum Sex Hormone-Binding Globulin (SHBG) plays an important role in breast cancer pathophysiology and risk definition, since it regulates the bioavailable fraction of circulating estradiol. We here summarize data reported over the years concerning the involvement of SHBG and SHBG polymorphisms in the definition of breast cancer risk. We also report what is known about the direct acti...
متن کاملSex hormone binding globulin, free estradiol index, and lipid profiles in girls with precocious puberty
PURPOSE Sex hormone-binding globulin (SHBG) modulates the availability of biologically active free sex hormones. The regulatory role of SHBG might be important in the relationship between hormone levels and the modification of lipid profiles in girls with precocious puberty. However, few studies have evaluated the relationship of SHBG, free estradiol index (FEI), and lipid levels in these girls...
متن کاملSerum levels of sex hormone-binding globulin (SHBG) are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men.
OBJECTIVE It is generally accepted that SHBG decreases the bioavailability and activity of testosterone (T). In in vitro experiments increased levels of SHBG will be associated with decreased levels of non-SHBG bound testosterone (non-SHBG-T). However, in vivo SHBG can alter both production and clearance rates and thus plasma levels of T. DESIGN AND PATIENTS In order to study the effect of SH...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1993
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199305001-00481